I run every day ~5 miles but do it barefooted on soft surface (water line at beach). I would not do it on concrete regardless how good the shoe support is. It's very important to have a well balanced body as you are putting it through higher stress, running or being a desk warrior. By that I mean symmetric use of the breathing mechanism (rib cage, muscles, etc.), symmetric use of the hips, symmetric gait. Any prior injury, medical intervention or repetitive-use trauma will affect your nervous system's willingness to load a limb, a hip, what have you.